NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.

Abstract

Nerve growth factor (NGF) is required for the trophic maintenance of postnatal sympathetic neurons. A significant portion of the growth-promoting activity of NGF is from NGF-dependent phosphorylation of the heterologous receptor tyrosine kinase, Ret. We found that NGF applied selectively to distal axons of sympathetic neurons maintained in compartmentalized… (More)

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@article{Pierchala2007NGFAT, title={NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.}, author={Brian A. Pierchala and Cynthia C Tsui and Jeffrey D Milbrandt and Eugene Malcolm Johnson}, journal={Journal of neurochemistry}, year={2007}, volume={100 5}, pages={1169-76} }