NGF and the Treatment of Alzheimer's Disease

  title={NGF and the Treatment of Alzheimer's Disease},
  author={L. Olson},
  journal={Experimental Neurology},
  • L. Olson
  • Published 1993
  • Psychology, Medicine
  • Experimental Neurology
Issues related to the possible treatment of Alzheimer's disease with nerve growth factor (NGF) are discussed. Animal research has demonstrated that the ascending cholinergic projections in the brain express low- and high-affinity receptors for NGF and are NGF-sensitive as well as probably NGF-dependent. Cholinergic lesions lead to cognitive disturbances, and treatment with NGF can improve cognitive behavior in animals. It thus seems reasonable to attempt to counteract the degeneration of… Expand
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