NGF and the Treatment of Alzheimer's Disease

  title={NGF and the Treatment of Alzheimer's Disease},
  author={L. Olson},
  journal={Experimental Neurology},
  • L. Olson
  • Published 1993
  • Psychology, Medicine
  • Experimental Neurology
  • Issues related to the possible treatment of Alzheimer's disease with nerve growth factor (NGF) are discussed. Animal research has demonstrated that the ascending cholinergic projections in the brain express low- and high-affinity receptors for NGF and are NGF-sensitive as well as probably NGF-dependent. Cholinergic lesions lead to cognitive disturbances, and treatment with NGF can improve cognitive behavior in animals. It thus seems reasonable to attempt to counteract the degeneration of… CONTINUE READING
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