NGF and BDNF expression drop off in neurally differentiated bone marrow stromal stem cells.

  title={NGF and BDNF expression drop off in neurally differentiated bone marrow stromal stem cells.},
  author={Mohammad Mehdi Yaghoobi and Masoud Torkzadeh Mahani},
  journal={Brain research},
Bone marrow stromal stem cells (BMSC) express two neurotrophins nerve growth factor (NGF) and brain derived growth factor (BDNF) constitutively and can be differentiated into neuronal-like cells and used to treat neural injuries and diseases. The neurotrophins are required for repair of neural tissues. However, it is not evident whether these cells supply the sufficient amounts of the functional growth factors following neuronal differentiation. This study investigates the expression of NGF… CONTINUE READING


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Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts.

Neuropathology : official journal of the Japanese Society of Neuropathology • 2007
View 2 Excerpts

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 1 Excerpt

Protective effects of bone marrow stromal cell transplantation in injured rodent brain : synthesis of neurotrophic factors

Q. R E F E R E N C E S Chen, Y. Long, +5 authors K. Yang
J . Neurosci . Res . • 2005

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