NGF and BDNF are differentially modulated by visual experience in the developing geniculocortical pathway.

@article{Schoups1995NGFAB,
  title={NGF and BDNF are differentially modulated by visual experience in the developing geniculocortical pathway.},
  author={Aniek A. Schoups and Robert C. Elliott and Wilma J Friedman and Ira B. Black},
  journal={Brain research. Developmental brain research},
  year={1995},
  volume={86 1-2},
  pages={326-34}
}
Neuronal activity and trophic factors have been implicated in shaping the connectivity of functional synaptic circuits. We studied the development and regulation by sensory input of the neurotrophins NGF, BDNF and NT-3 in the developing rat visual system. In the occipital cortex, NT-3 mRNA was transiently expressed in the neonate. In contrast, BDNF and NGF mRNA's increased during postnatal development, and reached mature levels around 3 weeks of age. BDNF mRNA was ten times more abundant than… CONTINUE READING
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