NGAL decreases E-cadherin-mediated cell–cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells

Abstract

Expression of neutrophil gelatinase-associated lipocalin (NGAL)/lipocalin2, a recently recognized iron regulatory protein that binds to matrix metalloproteinase-9 (MMP9), is increased in a spectrum of cancers, including those of the colorectum. Using colon carcinoma cell lines stably transfected with NGAL or antisense NGAL, we showed that NGAL… (More)
DOI: 10.1038/labinvest.2009.17

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@article{Hu2009NGALDE, title={NGAL decreases E-cadherin-mediated cell–cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells}, author={Limei Hu and Walter N. Hittelman and Tao Lu and Ping Ji and Ralph B. Arlinghaus and Ilya Shmulevich and Stanley R. Hamilton and Wei Zhang}, journal={Laboratory Investigation}, year={2009}, volume={89}, pages={531-548} }