NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion.

@article{Cattaruzza2013NG2CSPG4collagenTV,
  title={NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion.},
  author={Sabrina Cattaruzza and Pier Andrea Nicolosi and Paola Braghetta and L. Pazzaglia and Maria Serena Benassi and Piero Picci and Katia Lacrima and Daniela Zanocco and Erika Rizzo and William B Stallcup and Alfonso Colombatti and Roberto Perris},
  journal={Journal of molecular cell biology},
  year={2013},
  volume={5 3},
  pages={176-93}
}
In soft-tissue sarcoma patients, enhanced expression of NG2/CSPG4 proteoglycan in pre-surgical primary tumours predicts post-surgical metastasis formation and thereby stratifies patients into disease-free survivors and patients destined to succumb to the disease. Both primary and secondary sarcoma lesions also up-regulate collagen type VI, a putative… CONTINUE READING