NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

  title={NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.},
  author={Iain L O Buxton and Dennis J. Cheek and Delrae M. Eckman and David P. Westfall and Kenton M. Sanders and Kathleen D. Keef},
  journal={Circulation research},
  volume={72 2},
Analogues of L-arginine with modifications at the terminal guanidino nitrogen and/or the carboxyl terminus of the molecule have been widely used for their ability to inhibit the production of nitric oxide and are thought to be competitive antagonists of nitric oxide synthase. The present studies were designed to test the possibility that these agents are also muscarinic receptor antagonists. Acetylcholine produced concentration-dependent contraction of endothelium-denuded rabbit coronary artery… CONTINUE READING


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