NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.

@article{Buxton1993NGnitroLM,
  title={NG-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists.},
  author={Iain L O Buxton and Dennis J. Cheek and Delrae M. Eckman and David P. Westfall and Kenton M. Sanders and Kathleen D. Keef},
  journal={Circulation research},
  year={1993},
  volume={72 2},
  pages={387-95}
}
Analogues of L-arginine with modifications at the terminal guanidino nitrogen and/or the carboxyl terminus of the molecule have been widely used for their ability to inhibit the production of nitric oxide and are thought to be competitive antagonists of nitric oxide synthase. The present studies were designed to test the possibility that these agents are also muscarinic receptor antagonists. Acetylcholine produced concentration-dependent contraction of endothelium-denuded rabbit coronary artery… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 133 extracted citations

Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology • 2006
View 9 Excerpts
Highly Influenced

Central and peripheral haemodynamic effects of l-NAME infusion in healthy volunteers

European Journal of Clinical Pharmacology • 2003
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Characteriza - tion of muscarinic receptors of bovine coronary artery by functional and radioligand binding studies

F Brunner, E Kiihberger, J Schloos, WR Kukovetz
Eur J Pharmacol • 1991

Muscarinic receptors in canine colonic circular smooth muscle : I . Coexistence of M 2 and M 3 sub - types

L Zhang, B Horowitz, Buxton ILO
Mol Pharmacol • 1991

Char - acterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

DD Rees, Palmer RMJ, R Schulz, HF Hodson, S Moncada
Br J Pharmacol • 1990

Similar Papers

Loading similar papers…