NG-monomethyl-L-arginine increases platelet deposition on damaged endothelium in vivo. A scanning electron microscopic study.

@article{HerbaczyskaCedro1991NGmonomethylLarginineIP,
  title={NG-monomethyl-L-arginine increases platelet deposition on damaged endothelium in vivo. A scanning electron microscopic study.},
  author={Krystyna Herbaczyńska-Cedro and K Lembowicz and Barbara A. Pytel},
  journal={Thrombosis research},
  year={1991},
  volume={64 1},
  pages={1-9}
}
There is increasing evidence that nitric oxide (NO) synthetized in vascular endothelium and in platelets by NO synthase influences vascular tone, down regulates platelet function and platelet-vessel wall interaction both in vitro and in vivo. We investigated the effect of a NO synthase inhibitor, NG-mono-methyl-L-arginine (L-NMMA, 100 mg/kg iv) on platelet-endothelial cell interaction in rabbit arteries ex vivo using scanning electron microscope (SEM). The effect of L-NMMA was examined on… CONTINUE READING