NFkappaB pathway: a good signaling paradigm and therapeutic target.

@article{Tergaonkar2006NFkappaBPA,
  title={NFkappaB pathway: a good signaling paradigm and therapeutic target.},
  author={Vinay Tergaonkar},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 10},
  pages={
          1647-53
        }
}
  • Vinay Tergaonkar
  • Published in
    The international journal of biochemistry & cell…
    2006
NFkappaB was identified 20 years ago (Sen, R., & Baltimore, D. (1986) Cell, 46, 705-716) as a nuclear factor that binds the kappa light chain enhancer in B-cells (and hence, the name NFkappaB) and was shown to play roles in innate and adaptive immune responses. More recently, its role in many other cellular processes has become apparent. Perhaps, not surprisingly, deregulated activity of the NFkappaB pathway has been observed and linked to the progression of several human ailments, including… CONTINUE READING

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