NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis.

@article{Khnel2000NFkappaBMA,
  title={NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis.},
  author={Florian K{\"u}hnel and Lars Zender and Yasmin Paul and Maja Katrin Tietze and Francisco Javier Cubero and Michael P. Manns and Stefan Kubicka},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 9},
  pages={6421-7}
}
NFkappaB is an essential survival factor in several physiological conditions such as embryonal liver development and liver regeneration. However, NFkappaB is also a main mediator of the cellular response to a variety of extracellular stress stimuli, and it has been shown that some viral-induced host cell apoptosis appears to be dependent on NFkappaB activation. The activation of NFkappaB upon viral infection may be a rapid way of initiating an innate immune response against the viral particles… CONTINUE READING
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