NFkappaB activation is essential for miR-21 induction by TGFβ1 in high glucose conditions.


Transforming growth factor beta1 (TGFβ1) is a pleiotropic growth factor with a very broad spectrum of effects on wound healing. Chronic non-healing wounds such as diabetic foot ulcers express reduced levels of TGFβ1. On the other hand, our previous studies have shown that the microRNA miR-21 is differentially regulated in diabetic wounds and that it… (More)
DOI: 10.1016/j.bbrc.2014.08.035


  • Presentations referencing similar topics