NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.

@article{Andela2003NFkappaBAP,
  title={NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.},
  author={Valentine B Andela and Andrew H. Gordon and George Zotalis and Randy N. Rosier and Jeffrey J Goater and Gregory D. Lewis and Edward M Schwarz and J. Edward Puzas and Regis J O'keefe},
  journal={Clinical orthopaedics and related research},
  year={2003},
  volume={415 Suppl},
  pages={S75-85}
}
Prostate cancers frequently metastasize to bone and this accounts for substantial morbidity. We investigated the potential role of the transcription factor NFkappaB as a central regulator of prostate cancer metastasis using the prostate adenocarcinoma cell line, PC-3, in a series of in vitro studies. Wild type PC-3 cells (PC-3.WT) have high basal levels of NFkappaB signaling, otherwise absent in PC-3 cells stably expressing a mutant form of the inhibitory kappa B (IkappaB) protein alpha (PC-3… CONTINUE READING

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