NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.

@article{Katzenellenbogen2007NFX1123AP,
  title={NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.},
  author={Rachel A Katzenellenbogen and Erin M Egelkrout and Portia A. Vliet-Gregg and Lindy C Gewin and Philip R. Gafken and Denise A. Galloway},
  journal={Journal of virology},
  year={2007},
  volume={81 8},
  pages={3786-96}
}
Overcoming senescence signals in somatic cells is critical to cellular immortalization and carcinogenesis. High-risk human papillomavirus (HPV) can immortalize epithelial cells in culture through degradation of the retinoblastoma protein by HPV E7 and activation of hTERT transcription, the catalytic subunit of telomerase, by the heterodimer HPV E6/E6-associated protein (E6AP). Recent work in our laboratory identified a novel repressor of hTERT transcription, NFX1-91, which is targeted for… CONTINUE READING

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