NFKB1 insertion/deletion promoter polymorphism increases the risk of advanced ovarian cancer in a Chinese population.

@article{Fan2011NFKB1IP,
  title={NFKB1 insertion/deletion promoter polymorphism increases the risk of advanced ovarian cancer in a Chinese population.},
  author={Yaxin Fan and Weijian Yu and Ping Ye and Huali Wang and Zhongmin Wang and Qingli Meng and Ying Duan and Xiaohua Liang and Wanxin An},
  journal={DNA and cell biology},
  year={2011},
  volume={30 4},
  pages={241-5}
}
Ovarian cancer is the leading cause of death among all gynecological cancers. This is mainly attributed to its frequent presentation at an advanced stage (International Federation of Gynecology and Obstetrics stage III-IV). Nuclear factor-kappaB (NF-κB) is critically involved in the carcinogenesis and development of ovarian cancer. A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter region of the NFKB1 gene, which encodes the p50 subunit of the NF-κB protein, has… CONTINUE READING

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