NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.

  title={NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.},
  author={Taku Kobayashi and Katsuyoshi Matsuoka and Shehzad Zafar Sheikh and Houda Zghal Elloumi and Nobuhiko Kamada and Tadakazu Hisamatsu and Jonathan J. Hansen and Kevin R. Doty and Scott D Pope and Stephen T. Smale and Toshifumi Hibi and Paul B. Rothman and Masaki Kashiwada and Scott Eric Plevy},
  journal={Journal of immunology},
  volume={186 8},
Regulation of innate inflammatory responses against the enteric microbiota is essential for the maintenance of intestinal homeostasis. Key participants in innate defenses are macrophages. In these studies, the basic leucine zipper protein, NFIL3, is identified as a regulatory transcription factor in macrophages, controlling IL-12 p40 production induced by bacterial products and the enteric microbiota. Exposure to commensal bacteria and bacterial products induced NFIL3 in cultured macrophages… CONTINUE READING
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