NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.

  title={NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.},
  author={Masaki Kashiwada and N L Pham and Lecia L. Pewe and John T Harty and Paul B. Rothman},
  volume={117 23},
Antigen presentation by mature dendritic cells (DCs) is the first step for initiating adaptive immune responses. DCs are composed of heterogeneous functional subsets; however, the molecular mechanisms that regulate differentiation of specific DC subsets are not understood. Here, we report that the basic leucine zipper transcription factor NFIL3/E4BP4 is essential for the development of CD8α(+) conventional DCs (cDCs). Nfil3(-/-) mice specifically lack CD8α(+) cDCs but not CD8α(-) cDCs or… CONTINUE READING

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