NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF

@inproceedings{Fane2017NFIBMB,
  title={NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF},
  author={Mitchell E Fane and Yash Chhabra and David E.J. Hollingsworth and Jacinta L. Simmons and Loredana Spoerri and Tae Gyu Oh and Jagat Chauhan and Toby Chin and Lachlan Harris and Tracey J. Harvey and George E. O. Muscat and C. R. Goding and Richard A Sturm and Nikolas K. Haass and Glen M Boyle and Michael Piper and Aaron G Smith},
  booktitle={EBioMedicine},
  year={2017}
}
While invasion and metastasis of tumour cells are the principle factor responsible for cancer related deaths, the mechanisms governing the process remain poorly defined. Moreover, phenotypic divergence of sub-populations of tumour cells is known to underpin alternative behaviors linked to tumour progression such as proliferation, survival and invasion. In the context of melanoma, heterogeneity between two transcription factors, BRN2 and MITF, has been associated with phenotypic switching… CONTINUE READING
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The clonal evolution of tumor cell populations.

Science • 1976
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63–75 NFIB is a driver of small cell lung cancer progression in mice and marks metastatic disease in patients

M. E. Fane
EBioMedicine • 2017

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