NFH-LacZ transgenic mice: regional brain activity of cytochrome oxidase.

@article{Strazielle2002NFHLacZTM,
  title={NFH-LacZ transgenic mice: regional brain activity of cytochrome oxidase.},
  author={Catherine Strazielle and Martine Dubois and Jo{\"e}l Eyer and Robert Lalonde},
  journal={Experimental neurology},
  year={2002},
  volume={177 2},
  pages={521-30}
}
Expression of the NFH-LacZ fusion protein in transgenic mice causes an early accumulation of neurofilament proteins in the cell bodies of neurons, as well as a reduction of motor neuron axonal caliber and Purkinje cell number in the cerebellum. Young (3 month old) and older (12-20 months) NFH-LacZ transgenic mice were compared to normal controls for regional brain metabolism, as assessed by cytochrome oxidase (CO) activity. Irrespective of age, CO activity was reduced in three cerebellar… CONTINUE READING