NFBD1/Mdc1 mediates ATR-dependent DNA damage response.

  title={NFBD1/Mdc1 mediates ATR-dependent DNA damage response.},
  author={Aimin Peng and Phang-lang Chen},
  journal={Cancer research},
  volume={65 4},
Budding yeast Rad9 (scRad9) plays a central role in mediating Mec1-dependent phosphorylation by recruiting its downstream substrates. The human scRad9 orthologues 53BP1 and NFBD1 associate with ionizing radiation-induced foci (IRIF) at sites of DNA repair. RNAi-based gene silencing of 53BP1 or NFBD1 has shown impaired phosphorylation of SQ/TQ [ataxia-telangiectasia mutated/ATM and Rad3-related (ATM/ATR) substrates] at IRIF, intra-S, and G(2)-M checkpoints and has thereby revealed essential… CONTINUE READING


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