NFATc2-mediated repression of cyclin-dependent kinase 4 expression.


The calcineurin-regulated transcription factor, nuclear factor of activated T cells (NFAT), controls many aspects of T cell function. Here, we demonstrate that the calcineurin/NFAT pathway negatively regulates the expression of cyclin-dependent kinase 4 (CDK4). A canonical NFAT binding site was identified and found to be sensitive to calcium signals, FK506… (More)


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@article{Baksh2002NFATc2mediatedRO, title={NFATc2-mediated repression of cyclin-dependent kinase 4 expression.}, author={Shairaz Baksh and Hans Ragnar Widlund and Ashley A. Frazer-Abel and Jinyan Du and Susan P. Fosmire and D. Fisher and James A. DeCaprio and Jaime F Modiano and Steven J. Burakoff}, journal={Molecular cell}, year={2002}, volume={10 5}, pages={1071-81} }