NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

@inproceedings{Xiao2017NFATc2ET,
  title={NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma},
  author={Zhi-Jie Xiao and Jing Liu and Si-Qi Wang and Yun Zhu and Xu-Yuan Gao and Vicky Pui-Chi Tin and Jing Qin and Jun-Wen Wang and Maria Pik Wong},
  booktitle={eLife},
  year={2017}
}
Tumor-initiating cells (TIC) are dynamic cancer cell subsets that display enhanced tumor functions and resilience to treatment but the mechanism of TIC induction or maintenance in lung cancer is not fully understood. In this study, we show the calcium pathway transcription factor NFATc2 is a novel regulator of lung TIC phenotypes, including tumorspheres, cell motility, tumorigenesis, as well as in vitro and in vivo responses to chemotherapy and targeted therapy. In human lung cancers, high… CONTINUE READING