NFATc1 and NFATc2 together control both T and B cell activation and differentiation.

@article{Peng2001NFATc1AN,
  title={NFATc1 and NFATc2 together control both T and B cell activation and differentiation.},
  author={Stanford L. Peng and Andrea J. Gerth and Ann M. Ranger and L. H. Glimcher},
  journal={Immunity},
  year={2001},
  volume={14 1},
  pages={13-20}
}
NFAT transcription factors play critical roles in gene transcription during immune responses. To investigate further the two most prominent NFAT family members, NFATc1 and NFATc2, we generated mice bearing lymphoid systems devoid of both. Doubly deficient T cells displayed cell surface markers of activation yet were significantly deficient in the development of multiple effector functions, including Th cytokine production, surface effector molecule expression, and cytolytic activity… CONTINUE READING

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