NFATc is required for TGFbeta-mediated transcriptional regulation of fibronectin.

@article{Cobbs2007NFATcIR,
  title={NFATc is required for TGFbeta-mediated transcriptional regulation of fibronectin.},
  author={Scott L Cobbs and Jennifer L. Gooch},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={362 2},
  pages={288-94}
}
Calcineurin is an important regulator of extracellular matrix (ECM) accumulation in the kidney but functions in a cell-specific manner. Previously, we identified a novel role for calcineurin in mesangial cells where calcineurin activity is required for TGFbeta-mediated induction of fibronectin expression. In this study, we examined the role of the… CONTINUE READING