NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.

@article{Go2004NFAT5TonEBPMM,
  title={NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.},
  author={W. Go and Xuebin Liu and Michelle A Roti and Forrest Liu and S. Ho},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 29},
  pages={
          10673-8
        }
}
  • W. Go, Xuebin Liu, +2 authors S. Ho
  • Published 2004
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Osmotic stress responses are critical not only to the survival of unicellular organisms but also to the normal function of the mammalian kidney. However, the extent to which cells outside the kidney rely on osmotic stress responses in vivo remains unknown. Nuclear factor of activated T cells 5 (NFAT5)/tonicity enhancer binding protein (TonEBP), the only known osmosensitive mammalian transcription factor, is expressed most abundantly in the thymus and is induced upon lymphocyte activation. Here… Expand
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