NFAT1 C-Terminal Domains Are Necessary but Not Sufficient for Inducing Cell Death

@inproceedings{Faget2012NFAT1CD,
  title={NFAT1 C-Terminal Domains Are Necessary but Not Sufficient for Inducing Cell Death},
  author={Douglas V Faget and Pedro I. Lucena and Bruno Kaufmann Robbs and Jo{\~a}o P B Viola},
  booktitle={PloS one},
  year={2012}
}
The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes involved in differentiation, cell cycle and apoptosis. NFAT proteins share two conserved domains, the NFAT-homology region (NHR) and a DNA-binding domain (DBD). The N- and C-termini display two transactivation domains (TAD-N and TAD-C) that have low sequence similarity. Due to the high sequence conservation in the NHR and DBD, NFAT… CONTINUE READING