NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure.

@article{Walther2014NFATTF,
  title={NFAT transcription factor regulation by urocortin II in cardiac myocytes and heart failure.},
  author={Stefanie Walther and Sawsan Awad and Vassyl A. Lonchyna and Lothar A Blatter},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={306 6},
  pages={H856-66}
}
Urocortin II (UcnII), a cardioactive peptide with beneficial effects in normal and failing hearts, is also arrhythmogenic and prohypertrophic. We demonstrated that cardiac effects are mediated by a phosphatidylinositol-3 kinase (PI3K)/Akt kinase (Akt)/endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) signaling pathways. Nuclear factor of activated… CONTINUE READING