NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure

@article{Flockhart2008NFATRI,
  title={NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure},
  author={Ross J. Flockhart and Brian L Diffey and P M Farr and Jim J. Lloyd and Nick J. Reynolds},
  journal={The FASEB Journal},
  year={2008},
  volume={22},
  pages={4218 - 4227}
}
The nuclear factor of activated T cells (NFAT) transcription factors are regulated by calcium/calcineurin signals and play important roles in T cells, muscle, bone, and neural tissue. NFAT is expressed in the epidermis, and although recent data suggest that NFAT is involved in the skin's responses to ultraviolet radiation (UVR), the wavelengths of radiation that activate NFAT and the biological function of UV-activated NFAT remain undefined. We demonstrate that NFAT transcriptional activity is… CONTINUE READING