NFAT proteins: key regulators of T-cell development and function

  title={NFAT proteins: key regulators of T-cell development and function},
  author={Fernando Macian},
  journal={Nature Reviews Immunology},
  • F. Macian
  • Published 1 June 2005
  • Biology
  • Nature Reviews Immunology
Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance. The functional versatility of NFAT… 

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