NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation.

@article{Nguyen2009NFAT3IA,
  title={NFAT-3 is a transcriptional repressor of the growth-associated protein 43 during neuronal maturation.},
  author={Tuan Nguyen and Ricco Lindner and Andrea Tedeschi and Kirsi Forsberg and Andrew Green and Anja Wuttke and Perrine Gaub and Simone Di Giovanni},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 28},
  pages={18816-23}
}
Transcription is essential for neurite and axon outgrowth during development. Recent work points to the involvement of nuclear factor of activated T cells (NFAT) in the regulation of genes important for axon growth and guidance. However, NFAT has not been reported to directly control the transcription of axon outgrowth-related genes. To identify transcriptional targets, we performed an in silico promoter analysis and found a putative NFAT site within the GAP-43 promoter. Using in vitro and in… CONTINUE READING

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Regulates the Growth-associated Protein

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