NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response

@article{Graber2010NF45FA,
  title={NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response},
  author={Tyson Ernst Graber and Stephen D. Baird and Peter N Kao and Michael B. Mathews and Martin Holc{\'i}k},
  journal={Cell Death and Differentiation},
  year={2010},
  volume={17},
  pages={719-729}
}
Expression of the cellular inhibitor of apoptosis protein 1 (cIAP1) is unexpectedly repressed at the level of translation under normal physiological conditions in many cell lines. We have previously shown that the 5′ untranslated region of cIAP1 mRNA contains a stress-inducible internal ribosome entry site (IRES) that governs expression of cIAP1 protein. Although inactive in unstressed cells, the IRES supports cap-independent translation of cIAP1 in response to endoplasmic reticulum stress. To… CONTINUE READING