NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations

@inproceedings{Schroeder2014NF2MerlinIH,
  title={NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations},
  author={Rebecca Dunbar Schroeder and Laura S. Angelo and Razelle Kurzrock},
  booktitle={Oncotarget},
  year={2014}
}
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma. Somatic NF2 mutations have also been reported in a variety of cancers, but interestingly these mutations do not cause the same tumors that are common in hereditary neurofibromatosis 2, even though the same gene is involved and there is overlap in the site of… CONTINUE READING

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