NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations

Abstract

Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma. Somatic NF2 mutations have also been reported in a variety of cancers, but interestingly these mutations do not cause… (More)

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Cite this paper

@inproceedings{Schroeder2014NF2MerlinIH, title={NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations}, author={Rebecca Dunbar Schroeder and Laura S. Angelo and Razelle Kurzrock}, booktitle={Oncotarget}, year={2014} }