NF1 microdeletion breakpoints are clustered at flanking repetitive sequences.

@article{Dorschner2000NF1MB,
  title={NF1 microdeletion breakpoints are clustered at flanking repetitive sequences.},
  author={Michael Dorschner and Virginia P. Sybert and M. B. Weaver and Beth A. Pletcher and K. Stephens},
  journal={Human molecular genetics},
  year={2000},
  volume={9 1},
  pages={35-46}
}
Neurofibromatosis type 1 patients with a submicroscopic deletion spanning the NF1 tumor suppressor gene are remarkable for an early age at onset of cutaneous neurofibromas, suggesting the deletion of an additional locus that potentiates neurofibromagenesis. Construction of a 3.5 Mb BAC/PAC/YAC contig at chromosome 17q11.2 and analysis of somatic cell hybrids from microdeletion patients showed that 14 of 17 cases had deletions of 1.5 Mb in length. The deletions encompassed the entire 350 kb NF1… CONTINUE READING
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