NF1 mRNA biogenesis: effect of the genomic milieu in splicing regulation of the NF1 exon 37 region.

@article{Baralle2006NF1MB,
  title={NF1 mRNA biogenesis: effect of the genomic milieu in splicing regulation of the NF1 exon 37 region.},
  author={Marco Baralle and Nata{\vs}a Skoko and Anna Knezevich and Laura de Conti and Dario Motti and Madhuri Bhuvanagiri and Diana Baralle and Emanuele Buratti and Francisco E. Baralle},
  journal={FEBS letters},
  year={2006},
  volume={580 18},
  pages={4449-56}
}
We have studied the splicing regulation of NF1 exons 36 and 37. We show that they not only require an intact exonic Splicing Enhancer (ESE) within exon 37, but also need the genomic region stretching from exons 31 to 38. Any nucleotide change in two exon 37 third codon positions disrupts the ESE. The extent of exons 36 and 37 skipping due to a mutated ESE depends on the genomic context. This is a unique example of what may be a more general phenomena involved in the tuning of pre-mRNA… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…