NF1 Mutations Are Common in Desmoplastic Melanoma.

  title={NF1 Mutations Are Common in Desmoplastic Melanoma.},
  author={Thomas Wiesner and Maija Kiuru and Sasinya N. Scott and Maria E. Arcila and Allan C. Halpern and Travis J. Hollmann and Michael F. Berger and Klaus J. Busam},
  journal={The American journal of surgical pathology},
  volume={39 10},
Desmoplastic melanoma (DM) is a rare variant of melanoma with distinct clinical, histopathologic, and immunohistochemical features. Clinically, DM differs from conventional melanoma by a higher propensity for local recurrence and less frequent metastatic spread to regional lymph nodes. In its pure form, DM has a distinct appearance displaying a low density of fusiform melanocytes in a collagen-rich matrix. Whereas a number of mutations have been identified in primary melanoma, including BRAF… CONTINUE READING