NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.

@article{Zhang2009NFkappabFO,
  title={NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.},
  author={Yahong Zhang and Yingliang Wu and Di Wu and Shin-ichi Tashiro and Satoshi Onodera and Takashi Ikejima},
  journal={Archives of biochemistry and biophysics},
  year={2009},
  volume={489 1-2},
  pages={25-33}
}
In this study, we investigated the molecular mechanisms involving in oridonin-induced apoptosis and autophagy. We found that apoptosis and autophagy were simultaneously induced by oridonin time-dependently in HT1080 cells, and inhibition of autophagy by 3MA decreased oridonin-induced apoptosis, indicating that they act in synergy to mediate cell death. In addition, treatment with oridonin caused an increase in NF-kappaB and p53 activities in a time-dependent manner. Inhibition of NF-kappaB or… CONTINUE READING
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