NF-kappaB signaling: a tale of two pathways in skeletal myogenesis.

@article{Bakkar2010NFkappaBSA,
  title={NF-kappaB signaling: a tale of two pathways in skeletal myogenesis.},
  author={N. Bakkar and Denis C. Guttridge},
  journal={Physiological reviews},
  year={2010},
  volume={90 2},
  pages={
          495-511
        }
}
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either canonical (classical) NF-kappaB signaling by degrading the IkappaB inhibitor and releasing p65/p50 dimers to the nucleus, or causes p100 processing and nuclear translocation of RelB/p52 via a noncanonical… 

Figures from this paper

NF-κB and p38 MAPK: Major regulators in skeletal muscle development

The most recent reports on this aspect are included in this paper, and to further complete the picture between NF-κB and p38 MAPK will be filled with prospect.

NF-κB Signaling Pathways in Carcinogenesis

  • H. Nakshatri
  • Biology, Medicine
    Predictive Biomarkers in Oncology
  • 2018
Nuclear factor-kappaB (NF-κB) is a signal-activated transcription factor complex with two functional subunits and controls the expression of >600 genes in the human genome. This protein complex was

Reining in nuclear factor-kappaB in skeletal muscle disorders

Dissecting the crosstalk between NF-&kgr;B, its upstream mediators, and other signaling pathways is vital to the authors' understanding of how activation of this signaling pathway is mediated in various diseases.

Role and mechanisms of the NF-ĸB signaling pathway in various developmental processes.

Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis

A review of the functions of TWEAK, its receptor Fn14, and the associated signal transduction molecule, the cellular inhibitor of apoptosis 1 (cIAP1), in the regulation of myogenesis highlights the interplay between the two NF-κB pathways under physiological and pathological conditions.

Regulation of Skeletal Muscle Formation and Regeneration by the Cellular Inhibitor of Apoptosis 1 (cIAP1) Protein

Results identify cIAP1 as a regulator of myogenesis through its modulation of classical and alternative NF-κB signalling pathways, which acts to improve myogenesis and increase muscle resistance to damage.

Regulation of signal transduction by spatial parameters: a case in NF-κB oscillation.

regulation mechanisms of NF-κB are described, and the importance of a 'space' for the regulation of oscillation pattern of NF -κB is discussed, showing altered oscillationpattern by the change in spatial parameters such as diffusion coefficient, nuclear to cytoplasmic volume ratio (N/C ratio), and transport through nuclear membrane.

Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression.

PRAS40 promotes NF-κB transcriptional activity through association with p65

It is found that a small p65-derived peptide can disrupt the PRAS40–P65 association and significantly decrease NF-κB transcriptional activity, and this finding may help elucidate the pleiotropic functions of PRas40 in cells and suggest a novel therapeutic strategy in cancer patients with high expression ofPRAS40 and NF-σB.
...

References

SHOWING 1-10 OF 209 REFERENCES

NF-κB Regulation of YY1 Inhibits Skeletal Myogenesis through Transcriptional Silencing of Myofibrillar Genes

It is proposed that NF-κB regulation of YY1 and transcriptional silencing of myofibrillar genes represent a new mechanism by which NF-σκB functions in myoblasts to modulate skeletal muscle differentiation.

A fourth IkappaB protein within the NF-kappaB signaling module.

The characterization of a fourth inhibitor, nfkappab2/p100, that forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-kappaB activation and combined computational and experimental studies reveal that mutant cells with altered balances between canonical and noncanonical IkappaB proteins may exhibit inappropriate inflammation in response to developmental signals.

Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy.

The evidence presented here suggests that disuse muscle atrophy is associated with activation of an alternative NF-kappaB pathway that involves the activation of p50 but not p65, and the prototypical markers of cytokine-induced activation of NF- kappaB seen with disease-related wasting are not evident during disuse atrophy.

IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

A unique IKK/NF-κB signaling switch is revealed that functions to both inhibit differentiation and promote myotube homeostasis and overexpression or knockdown of IKKα regulates mitochondrial content and function.

p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.

This study provides the first evidence of a crosstalk between p38 MAPK and NF-kappaB signaling pathways during myogenesis, with IL-6 being one of the effectors of this promyogenic mechanism.

NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.

The role of NF-kappaB in cytokine-induced muscle degeneration was explored and its expression was down-regulated by TNF and IFN-gamma expression in mouse muscle in vivo, elucidate a possible mechanism that may underlie the skeletal muscle decay in cachexia.

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

It is shown that IKKα is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-κB target genes, and processing of the NF-σκB2 (p100) precursor.

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

It is shown that NF-κB also promotes cell growth in embryonic fibroblasts, correlating with its regulation of cyclin D1, and is identified as an important transcriptional target of NF-α, revealing a mechanism to explain how NF-β is involved in the early phases of the cell cycle to regulate cell growth and differentiation.

Myostatin and NF-κB Regulate Skeletal Myogenesis Through Distinct Signaling Pathways

Findings highlight the distinctive differences by which Mstn and NF-κB signal to regulate myogenesis, a finding which broadens the understanding of how these pathways function in both development and disease.
...