NF-kappaB signaling: a tale of two pathways in skeletal myogenesis.

  title={NF-kappaB signaling: a tale of two pathways in skeletal myogenesis.},
  author={N. Bakkar and Denis C. Guttridge},
  journal={Physiological reviews},
  volume={90 2},
NF-kappaB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either canonical (classical) NF-kappaB signaling by degrading the IkappaB inhibitor and releasing p65/p50 dimers to the nucleus, or causes p100 processing and nuclear translocation of RelB/p52 via a noncanonical… 

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