NF-kappaB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury.

@article{Souza2005NFkappaBPA,
  title={NF-kappaB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury.},
  author={Danielle G Souza and Ang{\'e}lica Thomas Vieira and Vanessa Pinho and Lirl{\^a}ndia Pires Sousa and Anderson Assunç{\~a}o Andrade and Cl{\'a}udio A Bonjardim and Michael J. McMillan and Michael N. Kahn and Mauro Martins Teixeira},
  journal={British journal of pharmacology},
  year={2005},
  volume={145 2},
  pages={
          246-54
        }
}
1 The nuclear translocation of transcription factors may be a critical factor in the intracellular pathway involved in ischaemia/reperfusion (I/R) injury. Here, we examined whether NF-kappaB and AP-1 participated in the cascade of events leading to TNF-alpha production, neutrophil recruitment, tissue injury and lethality following intestinal I/R. 2 The superior mesenteric artery (SMA) of mice was made ischaemic for 60 min followed by 30 min of reperfusion. The effects of NF-kappaB and AP-1 were… CONTINUE READING
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