NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.

@article{Zhou2008NFkappaBPI,
  title={NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.},
  author={Jiangbing Zhou and Hao Zhang and Peihua Gu and Jining Bai and Joseph B. Margolick and Ying Zhang},
  journal={Breast cancer research and treatment},
  year={2008},
  volume={111 3},
  pages={419-27}
}
Accumulating evidence indicates that breast cancer is caused by cancer stem cells and cure of breast cancer requires eradication of breast cancer stem cells. Previous studies with leukemia stem cells have shown that NF-kappaB pathway is important for leukemia stem cell survival. In this study, by using MCF7 sphere cells as model of breast cancer stem-like cells, we evaluated the effect of NF-kappaB pathway specific inhibitors on human breast cancer MCF7 sphere cells. Three inhibitors including… CONTINUE READING