NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.

@article{Yao2009NFkappaBPL,
  title={NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.},
  author={Zhenqiang Yao and Lianping Xing and Brendan F. Boyce},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 10},
  pages={3024-34}
}
TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-kappaB canonical signaling directly in osteoclast precursors (OCPs) to induce osteoclast formation in vitro. However, unlike RANKL, TNF does not activate the alternative NF-kappaB pathway efficiently to process the IkappaB protein NF-kappaB p100 to NF-kappaB p52, nor does it appear to induce osteoclast formation in vivo in the absence of RANKL. Here, we show that TNF limits RANKL… CONTINUE READING
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