NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha.

@article{Igarashi2006NFkappaBID,
  title={NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha.},
  author={Hideya Igarashi and Yoshihiro Baba and Yoshinori Nagai and Eijiro Jimi and Sankar Ghosh and Paul W. Kincade},
  journal={International immunology},
  year={2006},
  volume={18 5},
  pages={653-9}
}
Levels of the nuclear factor-kappa B (NF-kappaB)/Rel family of proteins are carefully modulated in differentiating lymphocytes, where these transcription factors are thought to be important for survival and fate decisions. In contrast, gene-targeting experiments have not revealed clear roles for these transcription factors in lymphopoiesis within bone marrow. Inhibition of NF-kappaB by introduction of mutated I kappa B alpha, a 'superinhibitor' of NF-kappaB, into hematopoietic stem cells or… CONTINUE READING
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