NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening.

Abstract

As a wide variety of pro-inflammatory cytokines are involved in the development of rheumatoid arthritis (RA), there is an urgent need for the discovery of novel therapeutic strategies. Among these, the inhibition of the NF-kappaB inducing kinase (NIK), a key enzyme of the NF-kappaB alternative pathway activation, represents a potential interesting approach… (More)
DOI: 10.1016/j.bmcl.2010.06.027

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