NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.

@article{Guttridge2000NFkappaBinducedLO,
  title={NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia.},
  author={Denis C. Guttridge and Marty W. Mayo and Lee V. Madrid and Chuan Ying Wang and Albert S Baldwin},
  journal={Science},
  year={2000},
  volume={289 5488},
  pages={
          2363-6
        }
}
MyoD regulates skeletal muscle differentiation (SMD) and is essential for repair of damaged tissue. The transcription factor nuclear factor kappa B (NF-kappaB) is activated by the cytokine tumor necrosis factor (TNF), a mediator of skeletal muscle wasting in cachexia. Here, the role of NF-kappaB in cytokine-induced muscle degeneration was explored. In differentiating C2C12 myocytes, TNF-induced activation of NF-kappaB inhibited SMD by suppressing MyoD mRNA at the posttranscriptional level. In… CONTINUE READING
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