NF-kappaB functions as a tumour promoter in inflammation-associated cancer.

@article{Pikarsky2004NFkappaBFA,
  title={NF-kappaB functions as a tumour promoter in inflammation-associated cancer.},
  author={Eli Pikarsky and Rinnat M. Porat and I. T. Stein and Rinat Abramovitch and S. Agrawal Amit and Shafika Kasem and Elena Gutkovich-Pyest and Simcha Urieli-Shoval and Eithan Galun and Yinon Ben-Neriah},
  journal={Nature},
  year={2004},
  volume={431 7007},
  pages={461-6}
}
The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, the latter accounting for approximately 20% of human cancer. Whereas the causal relationship between carcinogen exposure and cancer has been intensely investigated, the molecular and cellular mechanisms linking chronic inflammation to tumorigenesis remain largely unresolved. We proposed that activation of… CONTINUE READING
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