NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.

@article{Taganov2006NFkappaBdependentIO,
  title={NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses.},
  author={Konstantin D. Taganov and Mark P Boldin and Kuang-Jung Chang and David Baltimore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 33},
  pages={12481-6}
}
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the level of posttranscriptional repression. Expression profiling of 200 microRNAs in human monocytes revealed that several of them (miR-146a/b, miR-132, and miR-155) are endotoxin-responsive genes. Analysis of miR-146a and miR-146b gene expression… CONTINUE READING
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