NF-kappaB and apoptosis in colorectal tumourigenesis.

  title={NF-kappaB and apoptosis in colorectal tumourigenesis.},
  author={M{\'a}rcia M. Aranha and Pedro M. Borralho and Paula Ravasco and Isabel B Moreira da Silva and Luis Antonio Correia and Afonso Camilo Fernandes and Ma E Camilo and Cec{\'i}lia M. P. Rodrigues},
  journal={European journal of clinical investigation},
  volume={37 5},
BACKGROUND Nuclear factor-kappaB (NF-kappaB) may play an important role in colorectal tumourigenesis, controlling cell cycle and apoptosis gene expression. In addition, imbalances between cell proliferation and cell death are thought to underlie neoplastic development. The aims of this study were to investigate apoptosis and expression of several apoptosis-related proteins, and to determine correlations with colorectal tumour progression. MATERIALS AND METHODS Apoptosis was evaluated by the… CONTINUE READING