NF-kappaB and TNF-alpha stimulate androgen receptor expression in Sertoli cells.

@article{Delfino2003NFkappaBAT,
  title={NF-kappaB and TNF-alpha stimulate androgen receptor expression in Sertoli cells.},
  author={Frank J Delfino and Jared N. Boustead and Charity A Fix and William H. Walker},
  journal={Molecular and cellular endocrinology},
  year={2003},
  volume={201 1-2},
  pages={1-12}
}
Germ cell development within the mammalian testis requires testosterone stimulation of somatic Sertoli cells via interaction with intracellular androgen receptors (AR). AR expression levels undergo marked changes during spermatogenesis suggesting that the modulation of AR expression is an important mechanism to regulate Sertoli cell responsiveness to testosterone. An analysis of the AR gene promoter revealed three kappaB enhancer elements that interacted with Sertoli cell p50 and RelA NF-kappaB… CONTINUE READING

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