NF-kappaB and IKK as therapeutic targets in cancer.

  title={NF-kappaB and IKK as therapeutic targets in cancer.},
  author={Hong Jin Kim and Noel A Hawke and Albert S Baldwin},
  journal={Cell death and differentiation},
  volume={13 5},
The transcription factor NF-kappaB and associated regulatory factors (including IkappaB kinase subunits and the IkappaB family member Bcl-3) are strongly implicated in a variety of hematologic and solid tumor malignancies. A role for NF-kappaB in cancer cells appears to involve regulation of cell proliferation, control of apoptosis, promotion of angiogenesis, and stimulation of invasion/metastasis. Consistent with a role for NF-kappaB in oncogenesis are observations that inhibition of NF-kappaB… CONTINUE READING
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