NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model

@inproceedings{Connelly2011NFkappaBAW,
  title={NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model},
  author={Linda Connelly and Whitney J. Barham and Halina M. Onishko and Lianyi Chen and Taylor P. Sherrill and Tahera Zabuawala and Michael C. Ostrowski and Timothy S. Blackwell and Fiona E Yull},
  booktitle={Breast Cancer Research},
  year={2011}
}
Metastasis from primary tumor to the lungs is a major cause of the mortality associated with breast cancer. Both immune and inflammatory responses impact whether circulating mammary tumor cells successfully colonize the lungs leading to established metastases. Nuclear factor -kappaB (NF-κB) transcription factors regulate both immune and inflammatory responses mediated in part by the activities of macrophages. Therefore, NF-κB activity specifically within macrophages may be a critical… CONTINUE READING
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