NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells.

@article{Armstrong2006NFkappaBAU,
  title={NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells.},
  author={Kelly Armstrong and Craig N. Robson and Hing Y Leung},
  journal={The Prostate},
  year={2006},
  volume={66 11},
  pages={1223-34}
}
BACKGROUND Fibroblast growth factor 8 (FGF8) is over-expressed in prostate cancer (CaP) correlating with high-grade disease and reduced survival. The role of acetylation in transcriptional regulation of FGF8 was investigated using the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA). METHODS FGF8 transcriptional response to TSA was investigated by gene reporter assays, RT-PCR, and Western blotting. Chromatin immunoprecipitation (ChIP) assays were also performed. RESULTS FGF8 is… CONTINUE READING

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